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reduces BCL-2 and BCL-XL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcl-2 Family (2) Akt (1) Apoptosis (2) Caspase (2) Isotope-Labeled Compounds (1) PARP (1) PGE synthase (1) PI3K (1) Reactive Oxygen Species (1) TRP Channel (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Bcl-2 Family BCL6 Fat Mass and Obesity-associated Protein (FTO)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118119

CAY10526	PGE synthase	Cancer
CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC₅₀<5 μM) in three melanoma cell lines expressing mPGES1 .

HY-N0361

Dihydrocapsaicin 1 Publications Verification	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K	Cardiovascular Disease Neurological Disease
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased *Bcl-2, Bcl-xL* and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-N0361S

Dihydrocapsaicin-d3	Isotope-Labeled Compounds	Others
Dihydrocapsaicin-d₃is the deuterium labeledDihydrocapsaicin(HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased *Bcl-2, Bcl-xL* and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-163435

Anticancer agent 201	Apoptosis Caspase PARP Bcl-2 Family	Cancer
Anticancer agent 201 (Compound 2f) has IC₅₀ values in the low micromolar range for multiple tumor cell lines. Anticancer agent 201 is highly cytotoxic to CCRF-CEM cells in vitro, inducing apotosis by activating caspase-3 in the intrinsic mitochondrial pathway and lysis of PARP, as well as reducing the expression of *Bcl-2* and *Bcl-XL* proteins. Anticancer agent 201 can be used in cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0361

Dihydrocapsaicin 1 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Metabolic Disease Plants Solanaceae Disease Research Fields	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased *Bcl-2, Bcl-xL* and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

Cat. No.	Product Name	Chemical Structure

HY-N0361S

Dihydrocapsaicin-d3
Dihydrocapsaicin-d₃is the deuterium labeledDihydrocapsaicin(HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased *Bcl-2, Bcl-xL* and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃is the deuterium labeledDihydrocapsaicin(HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

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